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Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3
The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2′,5′-linked RNA molecules (2-5A) that activate regulated RNA decay in mammalia...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4386348/ https://ncbi.nlm.nih.gov/pubmed/25775560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419409112 |
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