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Mechanisms of angiotensin II stimulation of NCC are time-dependent in mDCT15 cells

Angiotensin II (ANG II) increases thiazide-sensitive sodium-chloride cotransporter (NCC) activity both acutely and chronically. ANG II has been implicated as a switch that turns WNK4 from an inhibitor of NCC into an activator of NCC, and ANG II's effect on NCC appears to require WNK4. Chronical...

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Bibliographic Details
Published in:Am J Physiol Renal Physiol
Main Authors: Ko, Benjamin, Mistry, Abinash, Hanson, Lauren, Mallick, Rickta, Hoover, Robert S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385889/
https://ncbi.nlm.nih.gov/pubmed/25651566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00465.2014
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