Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells

SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence. SERPINB3 has been reported to stimulate proliferation, inhibit apoptosis and, similar t...

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Publicado en:Oncotarget
Autores principales: Cannito, Stefania, Turato, Cristian, Paternostro, Claudia, Biasiolo, Alessandra, Colombatto, Sebastiano, Cambieri, Irene, Quarta, Santina, Novo, Erica, Morello, Elisabetta, Villano, Gianmarco, Fasolato, Silvano, Musso, Tiziana, David, Ezio, Tusa, Ignazia, Rovida, Elisabetta, Autelli, Riccardo, Smedile, Antonina, Cillo, Umberto, Pontisso, Patrizia, Parola, Maurizio
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385846/
https://ncbi.nlm.nih.gov/pubmed/25544768
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