Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A

Afatinib has anti-tumor effect in non-small cell lung carcinoma (NSCLC) with epidermal growth factor receptor (EGFR) mutation. We found afatinib can also induce apoptosis in NSCLC cells without EGFR mutation through CIP2A pathway. Four NSCLC cell lines (H358 H441 H460 and A549) were treated with afa...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chao, Ting-Ting, Wang, Cheng-Yi, Chen, Yen-Lin, Lai, Chih-Cheng, Chang, Fang-Yu, Tsai, Yi-Ting, Chao, Chung-Hao H., Shiau, Chung-Wai, Huang, Yuh-Chin T., Yu, Chong-Jen, Chen, Kuen-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385843/
https://ncbi.nlm.nih.gov/pubmed/25537503
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