An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques

The immunogenicity and protective efficacy of a candidate tetravalent dengue virus purified inactivated vaccine (TDENV PIV) formulated with alum or an Adjuvant System (AS01, AS03 tested at three different dose levels, or AS04) was evaluated in a 0, 1-month vaccination schedule in rhesus macaques. On...

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Vydáno v:Am J Trop Med Hyg
Hlavní autoři: Fernandez, Stefan, Thomas, Stephen J., De La Barrera, Rafael, Im-erbsin, Rawiwan, Jarman, Richard G., Baras, Benoît, Toussaint, Jean-François, Mossman, Sally, Innis, Bruce L., Schmidt, Alexander, Malice, Marie-Pierre, Festraets, Pascale, Warter, Lucile, Putnak, J. Robert, Eckels, Kenneth H.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society of Tropical Medicine and Hygiene 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385761/
https://ncbi.nlm.nih.gov/pubmed/25646261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.14-0268
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