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Synthesis and structure-activity relationships of a series 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter
The synthesis and SAR of 4-methoxy-3-(piperidin-4-yl) benzamides identified after a high-throughput screen of the MLPCN library is reported. SAR was explored around the 3-piperidine subtituent as well as the amide functionality of the reported compounds. Starting from the initial lead compounds, 1-7...
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| 發表在: | Bioorg Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4385452/ https://ncbi.nlm.nih.gov/pubmed/25801932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.02.058 |
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