Synthesis and structure-activity relationships of a series 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter

The synthesis and SAR of 4-methoxy-3-(piperidin-4-yl) benzamides identified after a high-throughput screen of the MLPCN library is reported. SAR was explored around the 3-piperidine subtituent as well as the amide functionality of the reported compounds. Starting from the initial lead compounds, 1-7...

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Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Bollinger, Sean R., Engers, Darren W., Ennis, Elizabeth A., Wright, Jane, Locuson, Charles W., Lindsley, Craig W., Blakely, Randy D., Hopkins, Corey R.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385452/
https://ncbi.nlm.nih.gov/pubmed/25801932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.02.058
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