Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity

Loss of function of DNA repair (DNAR) genes is associated with genomic instability and cancer predisposition; it also makes cancer cells reliant on a reduced set of DNAR pathways to resist DNA-targeted therapy, which remains the core of the anticancer armamentarium. Because the landscape of DNAR def...

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Veröffentlicht in:DNA Repair (Amst)
Hauptverfasser: Sousa, Fabricio G., Matuo, Renata, Tang, Sai-Wen, Rajapakse, Vinodh N., Luna, Augustin, Sander, Chris, Varma, Sudhir, Simon, Paul H.G., Doroshow, James H., Reinhold, William C., Pommier, Yves
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385398/
https://ncbi.nlm.nih.gov/pubmed/25758781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.01.011
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