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BMX negatively regulates BAK function thereby increasing apoptotic resistance to chemotherapeutic drugs
The ability of chemotherapeutic agents to induce apoptosis, predominantly via the mitochondrial (intrinsic) apoptotic pathway, is thought to be a major determinant of the sensitivity of a given cancer to treatment. Intrinsic apoptosis, regulated by the BCL-2 family, integrates diverse apoptotic sign...
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| Published in: | Cancer Res |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384990/ https://ncbi.nlm.nih.gov/pubmed/25649765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1340 |
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