YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules (SGs), which contain translationally silent mRNAs, preinitiation factors, and RNA-binding proteins. Y-box binding prote...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Somasekharan, Syam Prakash, El-Naggar, Amal, Leprivier, Gabriel, Cheng, Hongwei, Hajee, Shamil, Grunewald, Thomas G.P., Zhang, Fan, Ng, Tony, Delattre, Olivier, Evdokimova, Valentina, Wang, Yuzhuo, Gleave, Martin, Sorensen, Poul H.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2015
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384734/
https://ncbi.nlm.nih.gov/pubmed/25800057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201411047
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