YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules (SGs), which contain translationally silent mRNAs, preinitiation factors, and RNA-binding proteins. Y-box binding prote...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Somasekharan, Syam Prakash, El-Naggar, Amal, Leprivier, Gabriel, Cheng, Hongwei, Hajee, Shamil, Grunewald, Thomas G.P., Zhang, Fan, Ng, Tony, Delattre, Olivier, Evdokimova, Valentina, Wang, Yuzhuo, Gleave, Martin, Sorensen, Poul H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384734/
https://ncbi.nlm.nih.gov/pubmed/25800057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201411047
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