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CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation
Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous malformations (CCM), vascular lesions that most frequently occur in the brain and are strongly associated with hemorrhagic stroke, seizures, and other neurological disorders. CCM2 binds CCM3, but the molecular basis...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384732/ https://ncbi.nlm.nih.gov/pubmed/25825518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201407129 |
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