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Automated radiochemical synthesis and biodistribution of [(11)C]l-α-acetylmethadol ([(11)C]LAAM)
Long-acting opioid agonists methadone and l-α-acetylmethadol (LAAM) prevent withdrawal in opioid-dependent persons. Attempts to synthesize [(11)C]-methadone for PET evaluation of brain disposition were unsuccessful. Owing, however, to structural and pharmacologic similarities, we aimed to develop [(...
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| Publicado no: | Appl Radiat Isot |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384447/ https://ncbi.nlm.nih.gov/pubmed/24935116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2014.05.019 |
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