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Omega-3 polyunsaturated fatty acids upregulate 15-PGDH expression in cholangiocarcinoma cells by inhibiting miR-26a/b expression

Prostaglandin E(2) (PGE(2)) is a pro-inflammatory lipid mediator that promotes cancer growth. The 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes oxidation of the 15(S)-hydroxyl group of PGE(2), leading to its enzymatic inactivation. Therefore, 15-PGDH induction may offer a strategy to tre...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Yao, Lu, Han, Chang, Song, Kyoungsub, Zhang, Jinqiang, Lim, Kyu, Wu, Tong
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383692/
https://ncbi.nlm.nih.gov/pubmed/25691459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2561
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