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G-protein independent coupling of the MC4R to Kir 7.1 in hypothalamic neurons
The regulated release of anorexigenic α-MSH and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target sites in the CNS plays a fundamental role in the regulation of energy homeostasis. Both peptides bind with high affinity to the melanocortin-4 recept...
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出版年: | Nature |
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主要な著者: | , , , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2015
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4383680/ https://ncbi.nlm.nih.gov/pubmed/25600267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14051 |
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