Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding

Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of loci are unknown. Recent studies have suggested that many causal GWAS variants influence disease through altered transcriptional regulati...

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Bibliografiska uppgifter
I publikationen:PLoS Genet
Huvudupphovsmän: Reschen, Michael E., Gaulton, Kyle J., Lin, Da, Soilleux, Elizabeth J., Morris, Andrew J., Smyth, Susan S., O'Callaghan, Christopher A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383549/
https://ncbi.nlm.nih.gov/pubmed/25835000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005061
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