Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding

Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of loci are unknown. Recent studies have suggested that many causal GWAS variants influence disease through altered transcriptional regulati...

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Publicat a:PLoS Genet
Autors principals: Reschen, Michael E., Gaulton, Kyle J., Lin, Da, Soilleux, Elizabeth J., Morris, Andrew J., Smyth, Susan S., O'Callaghan, Christopher A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383549/
https://ncbi.nlm.nih.gov/pubmed/25835000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005061
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