Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2). However, the persistent translation of certain mRNAs is require...

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Bibliographic Details
Published in:eLife
Main Authors: Andreev, Dmitry E, O'Connor, Patrick BF, Fahey, Ciara, Kenny, Elaine M, Terenin, Ilya M, Dmitriev, Sergey E, Cormican, Paul, Morris, Derek W, Shatsky, Ivan N, Baranov, Pavel V
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383229/
https://ncbi.nlm.nih.gov/pubmed/25621764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03971
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