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Dietary pretreatment with green tea polyphenol, (−)-epigallocatechin-3-gallate reduces the bioavailability and hepatotoxicity of subsequent oral bolus doses of (−)-epigallocatechin-3-gallate()

Human case-studies have reported an association between green tea-based dietary supplements and hepatotoxicity. Studies have demonstrated the hepatotoxicity of high-dose oral bolus dosing with the tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) in mice and dogs. We examined the effect of pretre...

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Bibliographische Detailangaben
Veröffentlicht in:Food Chem Toxicol
Hauptverfasser: James, Karma D., Forester, Sarah C., Lambert, Joshua D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383035/
https://ncbi.nlm.nih.gov/pubmed/25528115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2014.12.009
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