Levofolene modulates apoptosis induced by 5-fluorouracil through autophagy inhibition: Clinical and occupational implications

5-Fluorouracil (5-FU), often used in combination with levofolene (LF), can induce, as an important side effect, the hand-foot syndrome (HFS) due to toxicity on keratinocytes. This can also damage workers involved in its handling. In the present study, we investigated the mechanisms of the toxicity i...

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Bibliographic Details
Published in:Int J Oncol
Main Authors: LAMBERTI, MONICA, PORTO, STEFANIA, ZAPPAVIGNA, SILVIA, STIUSO, PAOLA, TIRINO, VIRGINIA, DESIDERIO, VINCENZO, MELE, LUIGI, CARAGLIA, MICHELE
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383012/
https://ncbi.nlm.nih.gov/pubmed/25709090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2015.2904
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