Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells

OBJECTIVE: Significant reductions in gynecologic (GYN) cancer mortality and morbidity require treatments that prevent and reverse resistance to chemotherapy and radiation. The objective of this study was to determine if pharmacologic inhibition of key DNA damage response kinases in GYN cancers would...

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Vydáno v:Gynecol Oncol
Hlavní autoři: Teng, Pang-ning, Bateman, Nicholas W., Darcy, Kathleen M., Hamilton, Chad A., Maxwell, George Larry, Bakkenist, Christopher J., Conrads, Thomas P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382918/
https://ncbi.nlm.nih.gov/pubmed/25560806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2014.12.035
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