Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde – in vitro studies and computational modeling

PURPOSE: To elucidate additional substrate specificities of ALDH1B1 and determine the effect that human ALDH1B1 polymorphisms will have on substrate specificity. METHODS: Computational-based molecular modeling was used to predict the binding of the substrates propionaldehyde, 4-hydroxynonenal, nitro...

Full description

Saved in:
Bibliographic Details
Published in:Pharm Res
Main Authors: Jackson, Brian C., Reigan, Philip, Miller, Bettina, Thompson, David C., Vasiliou, Vasilis
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382438/
https://ncbi.nlm.nih.gov/pubmed/25413692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1564-3
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items