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Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde – in vitro studies and computational modeling
PURPOSE: To elucidate additional substrate specificities of ALDH1B1 and determine the effect that human ALDH1B1 polymorphisms will have on substrate specificity. METHODS: Computational-based molecular modeling was used to predict the binding of the substrates propionaldehyde, 4-hydroxynonenal, nitro...
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| Publicado no: | Pharm Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382438/ https://ncbi.nlm.nih.gov/pubmed/25413692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1564-3 |
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