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Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: Implications for their clinical pharmacology

PURPOSE: The purpose of the study was to evaluate the metabolism, pharmacokinetics and efficacy of phospho-NSAIDs in Ces1c-knockout mice. METHODS: Hydrolysis of phospho-NSAIDs by Ces1c was investigated using Ces1c-overexpressing cells. The rate of phospho-NSAID hydrolysis was compared between wild-t...

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Bibliografische gegevens
Gepubliceerd in:Pharm Res
Hoofdauteurs: Wong, Chi C., Cheng, Ka-Wing, Papayannis, Ioannis, Mattheolabakis, George, Huang, Liqun, Xie, Gang, Ouyang, Nengtai, Rigas, Basil
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382427/
https://ncbi.nlm.nih.gov/pubmed/25392229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1565-2
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