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Evaluation of conformational changes in diabetes-associated mutation in insulin A chain: A molecular dynamics study

Insulin plays a central role in the regulation of metabolism in humans. Mutations in the insulin gene can impair the folding of its precursor protein, proinsulin, and cause permanent neonatal-onset diabetes mellitus known as Mutant INS-gene induced Diabetes of Youth (MIDY) with insulin deficiency. T...

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Detalles Bibliográficos
Publicado en:Proteins
Main Authors: Kim, Yong Hwan, Kastner, Kevin, Abdul-Wahid, Badi, Izaguirre, Jesús A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382306/
https://ncbi.nlm.nih.gov/pubmed/25641314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24759
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