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Evaluation of conformational changes in diabetes-associated mutation in insulin A chain: A molecular dynamics study
Insulin plays a central role in the regulation of metabolism in humans. Mutations in the insulin gene can impair the folding of its precursor protein, proinsulin, and cause permanent neonatal-onset diabetes mellitus known as Mutant INS-gene induced Diabetes of Youth (MIDY) with insulin deficiency. T...
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| Publié dans: | Proteins |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4382306/ https://ncbi.nlm.nih.gov/pubmed/25641314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24759 |
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