Lipotoxicity disrupts incretin-regulated human β cell connectivity

Pancreatic β cell dysfunction is pathognomonic of type 2 diabetes mellitus (T2DM) and is driven by environmental and genetic factors. β cell responses to glucose and to incretins such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are altered in the disease...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Hodson, David J., Mitchell, Ryan K., Bellomo, Elisa A., Sun, Gao, Vinet, Laurent, Meda, Paolo, Li, Daliang, Li, Wen-Hong, Bugliani, Marco, Marchetti, Piero, Bosco, Domenico, Piemonti, Lorenzo, Johnson, Paul, Hughes, Stephen J., Rutter, Guy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382273/
https://ncbi.nlm.nih.gov/pubmed/24018562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68459
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