Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory functions that maintain normal neural function. For example, microglia clear misfolded proteins, elaborate trophic factors, and regulate and terminate toxic inflammation. In Alzheimer’s disease (AD), how...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Johansson, Jenny U., Woodling, Nathaniel S., Wang, Qian, Panchal, Maharshi, Liang, Xibin, Trueba-Saiz, Angel, Brown, Holden D., Mhatre, Siddhita D., Loui, Taylor, Andreasson, Katrin I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382270/
https://ncbi.nlm.nih.gov/pubmed/25485684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77487
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