Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory functions that maintain normal neural function. For example, microglia clear misfolded proteins, elaborate trophic factors, and regulate and terminate toxic inflammation. In Alzheimer’s disease (AD), how...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Johansson, Jenny U., Woodling, Nathaniel S., Wang, Qian, Panchal, Maharshi, Liang, Xibin, Trueba-Saiz, Angel, Brown, Holden D., Mhatre, Siddhita D., Loui, Taylor, Andreasson, Katrin I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382270/
https://ncbi.nlm.nih.gov/pubmed/25485684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77487
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