LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis

Epstein-Barr virus (EBV) infection transforms B cells in vitro and is associated with human B cell lymphomas. The major EBV oncoprotein, latent membrane protein 1 (LMP1), mimics constitutively active CD40 and is essential for outgrowth of EBV-transformed B cells in vitro; however, EBV-positive diffu...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ma, Shi-Dong, Xu, Xuequn, Plowshay, Julie, Ranheim, Erik A., Burlingham, William J., Jensen, Jeffrey L., Asimakopoulos, Fotis, Tang, Weihua, Gulley, Margaret L., Cesarman, Ethel, Gumperz, Jenny E., Kenney, Shannon C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382240/
https://ncbi.nlm.nih.gov/pubmed/25485679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76357
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