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Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

The K–Cl cotransporter KCC2 establishes the low intraneuronal Cl(−) levels required for the hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic g-aminobutyric acid receptors (GABA(A)Rs) and glycine receptors (GlyRs). Decreased KCC2-mediated Cl(−) extrusion and impaired hyperpol...

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Pubblicato in:Trends Neurosci
Autori principali: Kahle, Kristopher T., Deeb, Tarek Z., Puskarjov, Martin, Silayeva, Liliya, Liang, Bo, Kaila, Kai, Moss, Stephen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381966/
https://ncbi.nlm.nih.gov/pubmed/24139641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tins.2013.08.006
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