Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?

We have recently reported that therapeutic mesenchymal stromal cells (MSCs) have low engraftment and trigger the instant blood mediated inflammatory reaction (IBMIR) after systemic delivery to patients, resulting in compromised cell function. In order to optimize the product, we compared the immunom...

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Udgivet i:Stem Cells
Main Authors: Moll, Guido, Alm, Jessica J., Davies, Lindsay C., von Bahr, Lena, Heldring, Nina, Stenbeck-Funke, Lillemor, Hamad, Osama A., Hinsch, Robin, Ignatowicz, Lech, Locke, Matthew, Lönnies, Helena, Lambris, John D., Teramura, Yuji, Nilsson-Ekdahl, Kristina, Nilsson, Bo, Le Blanc, Katarina
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381870/
https://ncbi.nlm.nih.gov/pubmed/24805247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1729
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