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Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled

The cytoplasmic protein Dishevelled (Dvl) and the associated membrane-bound receptor Frizzled (Fz) are essential in canonical and noncanonical Wnt signaling pathways. However, the molecular mechanisms underlying this signaling are not well understood. By using NMR spectroscopy, we determined that an...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Wong, Hing-C., Bourdelas, Audrey, Krauss, Anke, Lee, Ho-Jin, Shao, Youming, Wu, Dianqing, Mlodzik, Marek, Shi, De-Li, Zheng, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381837/
https://ncbi.nlm.nih.gov/pubmed/14636582
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