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Identification of Tripeptides Recognized by the PDZ domain of Dishevelled

The development of inhibitors of Dishevelled (Dvl) PDZ protein-protein interactions attracts attention due to a possible application in drug discovery and development. Using nuclear magnetic resonance (NMR) spectroscopy, we found that a tripeptide VVV binds to the PDZ domain of Dvl, which is a key c...

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Hlavní autoři: Lee, Ho-Jin, Wang, Nick X., Shao, Youming, Zheng, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713185/
https://ncbi.nlm.nih.gov/pubmed/19157887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.12.060
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