Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects(1)(2)(3)(4)(5)

Background: Folic acid prevents neural tube closure defects (NTDs), but the causal metabolic pathways have not been established. Serine hydroxymethyltransferase 1 (SHMT1) is an essential scaffold protein in folate-dependent de novo thymidylate synthesis in the nucleus. SHMT1-deficient mice provide a...

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Vydáno v:Am J Clin Nutr
Hlavní autoři: Martiniova, Lucia, Field, Martha S, Finkelstein, Julia L, Perry, Cheryll A, Stover, Patrick J
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Nutrition 2015
Témata:
Gene-Nutrient Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381776/
https://ncbi.nlm.nih.gov/pubmed/25833982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.114.097279
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