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Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects(1)(2)(3)(4)(5)
Background: Folic acid prevents neural tube closure defects (NTDs), but the causal metabolic pathways have not been established. Serine hydroxymethyltransferase 1 (SHMT1) is an essential scaffold protein in folate-dependent de novo thymidylate synthesis in the nucleus. SHMT1-deficient mice provide a...
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| Опубликовано в: : | Am J Clin Nutr |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Nutrition
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4381776/ https://ncbi.nlm.nih.gov/pubmed/25833982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/ajcn.114.097279 |
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