Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells

Constitutively active receptor tyrosine kinases (RTKs) are known oncogenic drivers and provide valuable therapeutic targets in many cancer types. However, clinical efficacy of RTK inhibitors is limited by intrinsic and acquired resistance. To identify genes conferring resistance to inhibition of the...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Petti, Consalvo, Picco, Gabriele, Martelli, Maria Luisa, Trisolini, Elena, Bucci, Enrico, Perera, Timothy, Isella, Claudio, Medico, Enzo
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2014
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381590/
https://ncbi.nlm.nih.gov/pubmed/25473895
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