The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

Disappearance of the Barr body is considered a hallmark of cancer, although whether this corresponds to genetic loss or to epigenetic instability and transcriptional reactivation is unclear. Here we show that breast tumors and cell lines frequently display major epigenetic instability of the inactiv...

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Опубликовано в: :Genome Res
Главные авторы: Chaligné, Ronan, Popova, Tatiana, Mendoza-Parra, Marco-Antonio, Saleem, Mohamed-Ashick M., Gentien, David, Ban, Kristen, Piolot, Tristan, Leroy, Olivier, Mariani, Odette, Gronemeyer, Hinrich, Vincent-Salomon, Anne, Stern, Marc-Henri, Heard, Edith
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2015
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381521/
https://ncbi.nlm.nih.gov/pubmed/25653311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.185926.114
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