The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

Disappearance of the Barr body is considered a hallmark of cancer, although whether this corresponds to genetic loss or to epigenetic instability and transcriptional reactivation is unclear. Here we show that breast tumors and cell lines frequently display major epigenetic instability of the inactiv...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genome Res
Egile Nagusiak: Chaligné, Ronan, Popova, Tatiana, Mendoza-Parra, Marco-Antonio, Saleem, Mohamed-Ashick M., Gentien, David, Ban, Kristen, Piolot, Tristan, Leroy, Olivier, Mariani, Odette, Gronemeyer, Hinrich, Vincent-Salomon, Anne, Stern, Marc-Henri, Heard, Edith
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2015
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381521/
https://ncbi.nlm.nih.gov/pubmed/25653311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.185926.114
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