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Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance
HIV-1 protease inhibitors (PIs) are among the most effective antiretroviral drugs. They are characterized by highly cooperative dose-response curves that are not explained by current pharmacodynamic theory. An unresolved problem affecting the clinical use of PIs is that patients who fail PI-containi...
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| Publicado en: | J Clin Invest |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4381280/ https://ncbi.nlm.nih.gov/pubmed/23979165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67399 |
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