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Definition of a Molecular Pathway Mediating α-Synuclein Neurotoxicity

α-Synuclein physiologically chaperones SNARE-complex assembly at the synapse but pathologically misfolds into neurotoxic aggregates that are characteristic for neurodegenerative disorders, such as Parkinson's disease, and that may spread from one neuron to the next throughout the brain during P...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Burré, Jacqueline, Sharma, Manu, Südhof, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380997/
https://ncbi.nlm.nih.gov/pubmed/25834048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4650-14.2015
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