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α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
Physiologically, α-synuclein chaperones soluble NSF attachment protein receptor (SNARE) complex assembly and may also perform other functions; pathologically, in contrast, α-synuclein misfolds into neurotoxic aggregates that mediate neurodegeneration and propagate between neurons. In neurons, α-synu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210039/ https://ncbi.nlm.nih.gov/pubmed/25246573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416598111 |
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