Methionine Adenosyltransferase 2B–GIT1 Complex Serves as a Scaffold to Regulate Ras/Raf/MEK1/2 Activity in Human Liver and Colon Cancer Cells

Methionine adenosyltransferase 2B (MAT2B) encodes for variant proteins V1 and V2 that interact with GIT1 to increase ERK activity and growth in human liver and colon cancer cells. MAT2B or GIT1 overexpression activates MEK. This study explores the mechanism for MEK activation. We examined protein-pr...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Peng, Hui, Li, Tony W.H., Yang, Heping, Moyer, Mary P., Mato, Jose M., Lu, Shelly C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380842/
https://ncbi.nlm.nih.gov/pubmed/25794709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.12.016
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