Methionine Adenosyltransferase 2B–GIT1 Complex Serves as a Scaffold to Regulate Ras/Raf/MEK1/2 Activity in Human Liver and Colon Cancer Cells

Methionine adenosyltransferase 2B (MAT2B) encodes for variant proteins V1 and V2 that interact with GIT1 to increase ERK activity and growth in human liver and colon cancer cells. MAT2B or GIT1 overexpression activates MEK. This study explores the mechanism for MEK activation. We examined protein-pr...

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Vydáno v:Am J Pathol
Hlavní autoři: Peng, Hui, Li, Tony W.H., Yang, Heping, Moyer, Mary P., Mato, Jose M., Lu, Shelly C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2015
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380842/
https://ncbi.nlm.nih.gov/pubmed/25794709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.12.016
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