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Functional regulation of hypoxia inducible factor-1α by SET9 lysine methyltransferase
HIF-1α is degraded by oxygen-dependent mechanisms but stabilized in hypoxia to form transcriptional complex HIF-1, which transactivates genes promoting cancer hallmarks. However, how HIF-1α is specifically regulated in hypoxia is poorly understood. Here, we report that the histone methyltransferase...
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| Publié dans: | Biochim Biophys Acta |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4380656/ https://ncbi.nlm.nih.gov/pubmed/25637186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.01.011 |
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