An evolutionary approach to folding small alpha-helical proteins that uses sequence information and an empirical guiding fitness function.
Three short protein sequences have been guided by computer to folds resembling their crystal structures. Initially, peptide fragment conformations ranging in size from 9 to 25 residues were selected from a database of known protein structures. A fragment was selected if it was compatible with a segm...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1994
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43800/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8183927/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.10.4436 |
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