Loss of BMPR2 leads to high bone mass due to increased osteoblast activity

Imbalances in the ratio of bone morphogenetic protein (BMP) versus activin and TGFβ signaling are increasingly associated with human diseases yet the mechanisms mediating this relationship remain unclear. The type 2 receptors ACVR2A and ACVR2B bind BMPs and activins but the type 2 receptor BMPR2 onl...

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Publicat a:J Cell Sci
Autors principals: Lowery, Jonathan W., Intini, Giuseppe, Gamer, Laura, Lotinun, Sutada, Salazar, Valerie S., Ote, Satoshi, Cox, Karen, Baron, Roland, Rosen, Vicki
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379725/
https://ncbi.nlm.nih.gov/pubmed/25663702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.156737
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