Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications

RNA interference (RNAi) has great potential to treat human disease(1–3). However, in vivo delivery of short interfering RNAs (siRNAs), which are negatively charged double-stranded RNA macromolecules, remains a major hurdle(4–9). Current siRNA delivery has begun to move away from large lipid and synt...

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Publicat a:Nat Biotechnol
Autors principals: Meade, Bryan R, Gogoi, Khirud, Hamil, Alexander S, Palm-Apergi, Caroline, van den Berg, Arjen, Hagopian, Jonathan C, Springer, Aaron D, Eguchi, Akiko, Kacsinta, Apollo D, Dowdy, Connor F, Presente, Asaf, Lönn, Peter, Kaulich, Manuel, Yoshioka, Naohisa, Gros, Edwige, Cui, Xian-Shu, Dowdy, Steven F
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378643/
https://ncbi.nlm.nih.gov/pubmed/25402614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3078
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