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Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

Bioactive macromolecular peptides and oligonucleotides have significant therapeutic potential. However, due to their size, they have no ability to enter the cytoplasm of cells. Peptide/Protein transduction domains (PTDs), also called cell-penetrating peptides (CPPs), can promote uptake of macromolec...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lönn, Peter, Kacsinta, Apollo D., Cui, Xian-Shu, Hamil, Alexander S., Kaulich, Manuel, Gogoi, Khirud, Dowdy, Steven F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015074/
https://ncbi.nlm.nih.gov/pubmed/27604151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32301
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