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Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory

The activity-dependent refinement of neural circuit connectivity during critical periods of brain development is essential for optimized behavioral performance. We hypothesize that this mechanism is defective in fragile X syndrome (FXS), the leading heritable cause of intellectual disability and aut...

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Bibliographic Details
Published in:Development
Main Authors: Doll, Caleb A., Broadie, Kendal
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4378248/
https://ncbi.nlm.nih.gov/pubmed/25804740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.117127
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