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Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis

Matrix metalloproteinase (MMP) functions modulate synapse formation and activity-dependent plasticity, with MMP dysfunction implicated in Fragile X syndrome (FXS), a disease caused by the loss of the RNA binding protein FMRP and characterized by neurological dysfunction and intellectual disability....

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Publicado en:Sci Signal
Main Authors: Dear, Mary L., Shilts, Jarrod, Broadie, Kendal
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743058/
https://ncbi.nlm.nih.gov/pubmed/29114039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan3181
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